TEST MELISA comes from the acronym: Memory Lymphocyte Immunostimulation Assay. TYPE OF SAMPLE: Blood
The technique consists of a cell culture of lymphocytes in the presence of metals, which assesses the degree of lymphocyte proliferation.
Type I, II, and III hypersensitivities produce lymphocyte activation, (either IgG or IgE), and are therefore measured using traditional antibody counting techniques.
Type IV hypersensitivities only produce an increase in lymphocytes numbers, so the methodology used in the MELISA test is currently the only viable laboratory technique for counting them.
MELISA detects the immune reaction against metals. BIt determines reactivity and intensity of reaction to each metal tested.
When a hypersensitivity process takes place, the sole and minimum contact of that organism with the metal produces an allergic and pathological reaction. This is the reaction measured by MELISA Test, thus detecting which metals make the body react, after the first contact.
MELISA is the only scientifically validated blood test to diagnose type IV hypersensitivity.
It is carried out under a license granted by the Organization MELISA.
Currently, only 4 laboratories authorized by this organization analyze the test (Germany, Switzerland, Israel, and in Spain, Centro Diagnóstico Calderón), which has been analyzing it since 2014.
Multiple publications support the efficacy and clinical utility of the test MELISA
The metals to be analyzed can be included in standard panels, or in personalized panels according to the patient’s exposure to specific metals, their clinical history and their symptoms.
Basic panel: Ni, MeHg, Al, As, TiO2
Autism panel: Al, Hg, Mel-Hg, Ni, Pb, Timerosal
Basic amalgam panel: Cu, Hg, Ni, Ag y Sn
Amalgam panel + Root implats: Al, Be, Cd, Cr, Cu, Au, In, Hg, Ir, Metil-Hg, Mo, Ni, Pd, Fenil-Hg, Pt, Ag, Timerosal, Sn, TiO2, Zr
Complete amalgam panel: Cu, Ga, Au, In, Hg, Ir, Ni, Pd, Pt, Ag
Titanium implants panel: Al, Ni, TiO2, Ti (SO4)2
Tailored panel: Selection of specific metals adapted to the patient
From a long list, the most frequently analyzed metals are the following:
To contribute to the selection of the appropriate metals for each patient, the test MELISA includes an extensive questionnaire for the clinical history of the patient.
The analytical report expresses the indices obtained for each of the allergens studied along with advice based on the results obtained.
Two types of patients: Those with a genetic predisposition to develop a type IV hypersensitivity, those who are continuously or chronically exposed to metals and those who anticipate future exposure to metals on an ongoing basis.
The secondary effects produced by this exposure to metals can produce different pathologies, autoimmunities, or even specific symptoms.
Usually this patients has previously consulted different specialists, carrying out other diagnostic tests that have not found out the cause of their pathology, which is why MELISA is very useful and helfpful for them.
Symptoms and pathologies associated with exposure to metals